[Indocyanine green fluorescence angiography in Harada disease]

Indocyanine green fluorescence angiography (ICG angiography) can reveal choroidal circulation, and so it is used to observe uveitis. We examined 29 eyes of 15 patients with Harada disease using ICG angiography. In the early phase, filling delay of choroidal circulation was the most remarkable finding in cases with flat retinal detachment in the posterior pole. In the early to late phase choroidal vessels were indistinct, and speckled hypofluorescence on the diffuse background fluorescence was seen. Leakage from the choroid into the subretinal space was seen in ICG angiography at the same leak points seen in fluorescein angiography. In 3 patients, the area of retinal detachment showed hypofluoresence in the late phase. Areas of Dalen-Fuchs spots showed hypofluorescence. ICG angiography clearly revealed severe disturbance of choroidal circulation in Harada disease, and filling delay of the choroidal circulation and indistinct choroidal vessels correlated with the severity of this disease. ICG angiography helps to evaluate the pathology of Harada disease clinically.