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Related Experiment Videos

Routine thyroid function tests in infertile women: are they necessary?

E Shalev1, S Eliyahu, M Ziv

  • 1Department of Obstetrics and Gynecology, Central Emek Hospital, Afula, Israel.

American Journal of Obstetrics and Gynecology
|November 1, 1994
PubMed
Summary

Routine thyroid function tests in infertile women are not always necessary. Thyroid screening is most beneficial for infertile patients experiencing ovulatory dysfunction, not the general infertile population.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Clinical Diagnostics

Background:

  • Thyroid dysfunction is a known factor contributing to infertility.
  • Evaluating thyroid function is a common practice in infertility workups.
  • The utility of routine thyroid testing across all infertile populations requires clarification.

Purpose of the Study:

  • To determine the diagnostic yield of routine thyroid function tests in a cohort of infertile women.
  • To assess the prevalence of thyroid abnormalities among infertile women.
  • To identify specific subgroups of infertile women who may benefit most from thyroid screening.

Main Methods:

  • Retrospective analysis of 444 infertile women's medical records.
  • Categorization of patients into standard infertility groups.

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  • Measurement of plasma free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels.
  • Comparison of results against established normal reference ranges.

    • Main Results:

    • All recorded free thyroxine (fT4) values fell within the normal range (0.8-1.8 ng/ml).
    • Only three women (less than 1% of the cohort) had elevated thyroid-stimulating hormone (TSH) levels above the normal range (0.15-4.5 mIU/L).
    • The three women with abnormal TSH results also exhibited ovulatory dysfunction.

    Conclusions:

    • Routine thyroid function testing in all infertile women has a low diagnostic yield.
    • Thyroid function testing is more appropriate for infertile women with diagnosed ovulatory dysfunction.
    • Selective screening based on clinical presentation, such as ovulatory dysfunction, is recommended over universal screening in infertile populations.