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Glucose intolerance in chronic respiratory failure

S Umeki1

  • 1Department of Medicine, Toshida-kai Kumeda Hospital, Osaka, Japan.

Angiology
|November 1, 1994
PubMed
Summary

Patients with chronic respiratory failure often show impaired glucose tolerance, despite normal insulin secretion. This suggests a higher risk of glucose intolerance in this population.

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Area of Science:

  • Endocrinology
  • Pulmonology
  • Metabolic Disorders

Background:

  • Chronic respiratory failure (CRF) is associated with various comorbidities.
  • Nutritional status, indicated by low body mass index (BMI), is often compromised in CRF patients.
  • The metabolic implications of CRF, particularly glucose metabolism, require further investigation.

Purpose of the Study:

  • To investigate glucose metabolism in patients with chronic respiratory failure.
  • To assess glucose tolerance and insulin secretion patterns in this patient group.
  • To determine the prevalence of impaired glucose tolerance and diabetes mellitus in CRF.

Main Methods:

  • Conducted a 75-g oral glucose tolerance test (OGTT) on 18 patients with CRF.
  • Excluded patients with pre-existing hyperglycemia, glycosuria, or hepatic/pancreatic disorders.
  • Compared patient BMI to that of normal subjects and analyzed OGTT results.

Main Results:

  • 50% of CRF patients exhibited impaired glucose tolerance, and 34% showed a diabetes mellitus pattern.
  • Mean two-hour plasma glucose was 9.8 mmol/L.
  • Patients had significantly lower BMI (17.6 kg/m2) compared to controls (23.8 kg/m2).
  • Insulin secretion demonstrated a normal response to glucose loading.

Conclusions:

  • A significant proportion of chronic respiratory failure patients display glucose intolerance.
  • CRF patients maintain normal insulin secretion despite impaired glucose tolerance.
  • Low BMI in CRF patients may be linked to altered glucose metabolism.

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