[Effect of dibunol on the course of experimental sinusitis]

Experimental sinusitis in rabbits was induced by a chemical burn of the mucous membrane. Local application of dibunol decreased the intensity of the purulent inflammation in the sinuses and that of perifocal serous inflammation. Serous inflammation of the contralateral sinus was practically absent. The amount of the lipid peroxidation products in the circulating blood in rabbits receiving dibunol was close to the control and statistically lower than in animals not treated with dibunol. The activity of local acid phosphatase, glucuronidase, marker lysosomal hydrolases and that of myeloperoxidase was lower in animals treated with dibunol, particularly at the pick of inflammation, this was probably due to the dibunol stabilizing effect on the cell membranes.