[Experimental aspects of the CNS-insular system]

The work was aimed at detection and precise localization of the hypothalamic nuclei sensitive to insulin deficiency. For this purpose nuclei of the whole hypothalamic area of the brain were examined in rats with experimentally-induced alloxan diabetes. Only individual nuclei, particularly the supraoptic nucleus of the anterior hypothalamus and the ventro-medial and the arcuate nuclei of the medial hypothalamus proved to react to insulin deficiency. The nuclei of the posterior hypothalamus failed to react to insulin deficiency. Possible ways and methods of participation of the insulin-dependent areas of the hypothalamus in the regulation of the endocrine function of the pancreas are discussed.