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Updated: Jul 28, 2026
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Respiratory allergy: hazard identification and risk assessment
G Briatico-Vangosa1, C L Braun, G Cookman
1Himont, Milan, Italy.
Summary
Identifying respiratory sensitizers is crucial for preventing occupational asthma. Promising animal models, like mouse IgE and guinea pig tests, require further development for reliable risk assessment.
Area of Science:
- Occupational health
- Immunology
- Toxicology
Background:
- Occupational asthma is a significant health issue caused by industrial chemicals and proteins.
- Current methods for predicting respiratory sensitization are limited and lack validation.
Purpose of the Study:
- To review clinical syndromes and mechanisms of occupational respiratory hypersensitivity.
- To evaluate current methods for identifying potential respiratory allergens.
- To highlight the need for validated predictive methods for respiratory sensitizers.
Main Methods:
- Review of clinical syndromes and immunological mechanisms.
- Assessment of existing predictive methods for respiratory allergens.
- Evaluation of animal models: mouse IgE test and guinea pig models.
Main Results:
- Reactivity with proteins is likely relevant for sensitization, but structure-based prediction is insufficient.
- Mouse models focus on sensitization induction; guinea pig models focus on elicitation reactions.
- No fully validated or internationally harmonized predictive methods currently exist.
Conclusions:
- Early identification of respiratory sensitizers is urgently needed due to severe health risks.
- Further development and validation of mouse IgE and guinea pig models are a priority.
- Validated methods will enable risk assessment for both sensitization induction and allergic elicitation.
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