[The effect of general anesthesia and its components on free-radical processes]

The problem of free-radical production in biological objects is discussed with emphasis laid on the influence exerted by general anesthesia and its components on free-radical processes. Free radicals are characterized by enhanced biological activity and potentiality to damage cellular structures and composition of the biological membranes, with changes in enzyme activity resulting in cell function and substance metabolism impairment. It is of interest to note the pro-oxidant effect of some anesthetics and drugs used in the course of general anesthesia. Contemporary multicomponent general anesthesia is accomplished with the aid of a large number of drugs, having different physico-chemical properties, and affecting directly or indirectly the processes of peroxide oxidation of lipids in the body. The role of antioxidants in eliminating the adverse sequels of lipid peroxide oxidation disorders id comprehensively discussed under a separate heading.