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Updated: Jul 30, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
[Development of methods of esophagoplasty in children]
Insights
This study details 50 years of progress in artificial esophagus surgery, refining techniques to significantly reduce complications and mortality. Retrosternal coloesophagoplasty has improved outcomes for pediatric patients requiring esophageal reconstruction.
Area of Science:
- Pediatric Surgery
- Gastrointestinal Surgery
- Surgical Innovation
Abstract:
In the Clinic of Pediatric Surgery of the Russian State Medical University 310 operations for esophagoplasty were performed using segments of the small and large intestine. The 50-year progress in the creation of an artificial esophagus is characterized by gradual advancement from prethoracic plasty after Roux-Herzen-Yudin to the refined method of retrosternal coloesophagoplasty. The incidence of the characteristic postoperative complications reduced by 3 to 10 times, necrosis of the transplant was practically not encountered, the mortality reduced to 1.2%, and the functional results improved significantly.
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