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Published on: July 11, 2014
Reversed-phase solvent-gradient HPLC retention indexes of drugs
Abstract:
A high-performance liquid chromatographic (HPLC) system has been developed in which ionized basic drugs and nonionized drugs elute in efficient and reproducible bands. The effects of different HPLC systems and solvent-gradient rates on the reproducibility of retention times and normalized retention data were investigated. The retention indexes of 469 drugs were determined on this system and compared with the retention indexes of drugs in common from a previously reported retention index database.
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