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MRI of the brain in muscle-eye-brain (MEB) disease
L Valanne1, H Pihko, K Katevuo
1Department of Radiology, Children's Hospital, University of Helsinki, Finland.
Neuroradiology
|August 1, 1994
Abstract:
Muscle-eye-brain (MEB) disease belongs to the spectrum of rare congenital syndromes with migration disorders of the brain and muscular dystrophy, along with the Walker-Warburg syndrome and Fukuyama congenital muscular dystrophy. Their features overlap, and differential diagnosis presents some difficulties. We examined the brain of 10 patients with MEB using high-field MRI and found a uniform pattern consisting of a pachygyria-type cortical migration disorder, septal and corpus callosum defects and severe hypoplasia of the pons in 7 of them.