Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is immune function better preserved after laparoscopic versus open colon resection?

M Bessler1, R L Whelan, A Halverson

  • 1Columbia University, New York, NY.

Surgical Endoscopy
|August 1, 1994
PubMed
Summary

Laparoscopic colon resection in pigs showed a 20% stronger delayed-type hypersensitivity response compared to open surgery, indicating a potentially better immunologic recovery. Cortisol levels were also monitored in this preliminary study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variations in reactive oxygen species between mouse strains.

Blood cells, molecules & diseases·2015
Same author

Impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions.

Journal of internal medicine·2011
Same author

Recombinant tissue-type plasminogen activator in the treatment of acute renal artery thrombosis after kidney transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
Same author

Sex differences in visceral adipose tissue post-bariatric surgery compared to matched non-surgical controls.

International journal of body composition research·2010
Same author

Minimally invasive colon resection for malignant colonic conditions is associated with a transient early increase in plasma sVEGFR1 and a decrease in sVEGFR2 levels after surgery.

Surgical endoscopy·2009
Same author

Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass.

International journal of obesity (2005)·2009

Area of Science:

  • Immunology
  • Surgical Innovation
  • Veterinary Medicine

Background:

  • Minimally invasive surgery, such as laparoscopic procedures, is increasingly adopted in veterinary medicine.
  • Understanding the immunologic impact of surgical techniques is crucial for patient outcomes.
  • Previous studies have suggested potential differences in stress response and immune function between laparoscopic and open surgeries.

Purpose of the Study:

  • To compare the immunologic responses to laparoscopic versus standard open colon resection in pigs.
  • To investigate potential mediators, such as cortisol levels and delayed-type hypersensitivity (DTH), of any observed differences.

Main Methods:

  • A preliminary study involving 20 pigs, divided into two groups of 10.
  • One group underwent laparoscopic colon resection, while the other had an open colon resection.

Related Experiment Videos

  • Immunologic response was assessed by measuring serum cortisol levels and a DTH skin test using a common antigen.
  • Measurements were taken preoperatively, intraoperatively, and postoperatively on days 1 and 2.

    • Main Results:

    • Pigs undergoing laparoscopic resection exhibited a significantly greater DTH response (1.54 cm at 48h, 1.53 cm at 72h) compared to those in the open surgery group (1.24 cm at 48h, 1.32 cm at 72h).
    • The difference in DTH response between the groups was statistically significant (P < 0.05) at both 48 and 72 hours.
    • Cortisol levels were also monitored, though the abstract does not detail specific findings for cortisol.

    Conclusions:

    • Laparoscopic colon resection may elicit a more robust immunologic response compared to open surgery in pigs.
    • The enhanced DTH response suggests a potentially modulated immune status following minimally invasive procedures.
    • Further research is warranted to elucidate the specific immunologic mechanisms and clinical implications.