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Related Experiment Videos

Oral bacteriotherapy for viral gastroenteritis

E Isolauri1, M Kaila, H Mykkänen

  • 1Department of Clinical Medicine, University of Tampere, Finland.

Digestive Diseases and Sciences
|December 1, 1994
PubMed
Summary

Oral Lactobacillus GG shortened rotavirus diarrhea in children. This probiotic intervention reduced urease-producing bacteria, suggesting a way to restore microbial balance during illness.

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Area of Science:

  • Pediatrics
  • Microbiology
  • Gastroenterology

Background:

  • Rotavirus is a common cause of acute diarrhea in children.
  • Diarrhea can be associated with alterations in gut microbial composition and function.
  • Urease-producing bacteria may play a role in the second phase of rotavirus-induced diarrhea.

Purpose of the Study:

  • To evaluate the efficacy of Lactobacillus casei strain GG (LGG) in treating acute rotavirus diarrhea in children.
  • To investigate the impact of LGG supplementation on the fecal bacterial enzyme profile during rotavirus infection.

Main Methods:

  • A randomized controlled trial was conducted with 42 children aged 5-28 months with acute rotavirus diarrhea.
  • The study group received oral LGG (10^10 colony-forming units twice daily for five days) post-rehydration.

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  • The control group received standard oral rehydration without LGG.

    • Main Results:

    • Lactobacillus GG was detected in 83% of the feces in the study group.
    • The duration of diarrhea was significantly shortened in the LGG group compared to the control group.
    • LGG supplementation prevented the transient increase in fecal urease activity observed in the control group during diarrhea.

    Conclusions:

    • Oral administration of Lactobacillus GG is effective in shortening the duration of acute rotavirus diarrhea in children.
    • LGG supplementation may counteract the overgrowth of urease-producing bacteria associated with rotavirus infection.
    • Bacteriotherapy with probiotics shows promise in managing rotavirus-induced gastrointestinal disturbances.