Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple mathematical model for the functional peptide/MHC/TCR interactions

G Eberl1, M A Roggero, G Corradin

  • 1Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Journal of Immunology (Baltimore, Md. : 1950)
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RORγt, a multitask nuclear receptor at mucosal surfaces.

Mucosal immunology·2016
Same author

[Austrian nutrition and lifestyle recommendations for gout and hyperuricemia].

Zeitschrift fur Rheumatologie·2015
Same author

Addressing the experimental variability associated with the microbiota.

Mucosal immunology·2015
Same author

The "psychomicrobiotic": Targeting microbiota in major psychiatric disorders: A systematic review.

Pathologie-biologie·2014
Same author

Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.

Mucosal immunology·2014
Same author

Development and function of intestinal innate lymphoid cells.

Current opinion in immunology·2012

This study presents a mathematical model for T cell activation, explaining key immune responses like anergy and tolerance through T cell receptor (TCR) and peptide-MHC interactions.

Area of Science:

  • Immunology
  • Computational Biology
  • Biophysics

Background:

  • T cell activation is crucial for adaptive immunity.
  • This process depends on the specific interaction between T cell receptors (TCRs) and peptide-MHC complexes on antigen-presenting cells (APCs).

Purpose of the Study:

  • To develop a mathematical model for the trimolecular interaction of TCRs, peptide-MHC, and APCs.
  • To demonstrate the model's predictive power in experimental settings and explain complex immune phenomena.

Main Methods:

  • Construction of a mathematical model based on chemical and statistical principles.
  • Validation of the model using in vitro peptide antigen titration experiments.

Main Results:

  • The model accurately predicts T cell activation responses.

Related Experiment Videos

  • The model provides mechanistic insights into phenomena such as anergy, tolerance, and thymic selection.

    • Conclusions:

    • A quantitative model can effectively describe T cell activation dynamics.
    • This modeling approach offers a framework for understanding diverse cellular immunity mechanisms.