Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[T cell selection and tolerance induction in the thymus]

H Tamura, H Yamamoto

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |November 1, 1994
    PubMed
    Summary

    T cells learn to distinguish self from non-self during thymic development. Co-stimulatory signals are crucial for T cell survival, preventing anergy or deletion.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cell cycle modulation by hematopoietic growth factors in myelodysplastic syndromes: analysis by three-color flow cytometry.

    Experimental hematology·1997
    Same author

    Eradication of Helicobacter pylori in patients with end-stage renal disease under dialysis treatment.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·1997
    Same author

    [Aprotinin 2 million KIU reduces perioperative blood loss in patients undergoing primary total hip replacement].

    Masui. The Japanese journal of anesthesiology·1997
    Same author

    Plasma (1-->3)-beta-D-glucan assay and immunohistochemical staining of (1-->3)-beta-D-glucan in the fungal cell walls using a novel horseshoe crab protein (T-GBP) that specifically binds to (1-->3)-beta-D-glucan.

    Journal of clinical laboratory analysis·1997
    Same author

    The spread of methicillin-resistant Staphylococcus aureus in a rural community: will it become a common microorganism colonizing among the general population?

    Surgery today·1997
    Same author

    (1-->3)-beta-D-glucan determination in rat organs with limulus coagulation factor G.

    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie·1997

    Area of Science:

    • Immunology
    • Cellular Biology

    Context:

    • T cells are critical immune cells that undergo selection in the thymus.
    • Mechanisms of central tolerance (thymic deletion) and peripheral tolerance (anergy) are essential for immune homeostasis.

    Purpose:

    • To elucidate the role of T cell receptor signaling and co-stimulation in T cell fate determination.
    • To understand the mechanisms governing T cell tolerance and activation.

    Summary:

    • During thymic development, T cells undergo selection, with self-reactive cells deleted or inactivated.
    • T cell activation and tolerance are regulated by T cell receptor signaling strength and co-stimulatory signals.
    • Absence of co-stimulation leads to anergy or deletion, while its presence promotes T cell proliferation and survival.

    Impact:

    • Provides insights into the molecular basis of immune tolerance.
    • Informs strategies for modulating T cell responses in autoimmunity and transplantation.

    Related Experiment Videos