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[Target antigens in neuroimmunological diseases]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 1, 1994
Summary
This review details target antigens for various neuroimmunological diseases, including specific antibodies linked to conditions like multiple sclerosis and myasthenia gravis. Understanding these antigens aids in diagnosing and potentially treating these complex neurological disorders.
Area of Science:
- Neuroimmunology
- Neurology
- Immunology
Context:
- Neuroimmunological diseases involve the immune system attacking the nervous system.
- Identifying specific target antigens is crucial for diagnosis and understanding disease mechanisms.
- A wide range of neurological disorders have autoimmune components.
Purpose:
- To review and catalog the known target antigens associated with various neuroimmunological diseases.
- To provide a comprehensive reference for clinicians and researchers.
- To highlight the diversity of antigens implicated in nervous system autoimmunity.
Summary:
- The review lists specific antigens targeted in conditions such as limbic encephalitis (ple21), paraneoplastic cerebellar degeneration (PCD17, CDR62, CDR34, CZF), and multiple sclerosis (myelin basic protein, proteolipid protein, myelin-oligodendrocyte glycoprotein).
- It also covers antigens for stiff-man syndrome (glutamic acid decarboxylase), amyotrophic lateral sclerosis (GM1 ganglioside), myasthenia gravis (acetylcholine receptor), and Guillain-Barré syndrome (GM1 ganglioside), among others.
- Antigens like band 3, visinin-like substance, peripheral nerve K+ channel, synaptotagmin, GQ1b ganglioside, myelin-associated glycoprotein, HuD, tRNA, and HSP65 are associated with chorea-acanthocytosis, CAR syndrome, Isaacs syndrome, Lambert-Eaton syndrome, Fisher syndrome, IgM paraproteinemic neuropathy, paraneoplastic sensory neuropathy, and polymyositis, respectively.
Impact:
- Provides a foundational resource for developing diagnostic biomarkers.
- Facilitates research into the pathogenesis of neuroimmunological disorders.
- Informs the development of targeted immunotherapies for neurological conditions.