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Age-related changes in transcriptional and posttranscriptional regulation of the dopaminergic system
1Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
Life Sciences
|January 1, 1994
Abstract:
Loss of striatal dopamine receptors is a major cause of decreased motor control and a robust biomarker of aging. Mechanisms of receptor loss include both neuronal death and decreased expression of receptor genes at the transcriptional and translational levels.