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Updated: Sep 16, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Neurocysticercosis with initial clinical picture of acute meningitis]
A M Bonametti1, J L Baldy, A L Bortoliero
1Departamento de Clínica Médica, Universidade Estadual de Londrina, Paraná, Brasil.
Abstract:
Twenty seven cases of neurocysticercosis, with clinical picture of acute meningitis, are described. Twenty (74.1%) patients are male; the age was 4 to 42 years (23.6 +/- 11.7 years). The etiologic diagnosis was defined by the complement fixation test (Weinberg) and/or enzyme-linked immunosorbent assay (ELISA) for cysticercosis in the cerebrospinal fluid (c. s. f.). Six patients that realized cranial computerized tomographic scan resembling neurocysticercosis. Twenty one (77.8%) have predominance of lymphomononuclear cells in the c. s. f. obtained in the admission to the hospital; in 6 (22.2%) there were predominance of polymorphonuclear neutrophils. In this c. s. f. lymphomononuclear pleocytosis and in three that have c. s. f. neutrophil pleocytosis, suggesting the diagnosis of neurocysticercosis. The treatment of acute neurocysticercosis was made with dexamethasone. All the patients survived and were transferred to the ambulatory of Neurology for follow-up and complementary treatment.
Insights
Neurocysticercosis presenting as acute meningitis was diagnosed in 27 patients using serological tests and CSF analysis. Dexamethasone treatment led to survival in all cases, highlighting effective management strategies for this parasitic infection.
Area of Science:
- Neurology
- Infectious Diseases
- Parasitology
Context:
- Neurocysticercosis is a significant cause of neurological morbidity.
- Acute meningitis presentation is a less common but critical manifestation.
- Timely diagnosis and management are crucial for patient outcomes.
Purpose:
- To describe the clinical features, diagnostic methods, and treatment outcomes of neurocysticercosis presenting as acute meningitis.
- To evaluate the utility of serological tests and cerebrospinal fluid (CSF) analysis in diagnosing neurocysticercosis.
- To assess the efficacy of dexamethasone in managing acute neurocysticercosis.
Summary:
- Twenty-seven cases of neurocysticercosis with acute meningitis were analyzed.
- Diagnosis involved complement fixation tests, ELISA for cysticercosis in CSF, and CSF cell counts (lymphomononuclear or polymorphonuclear pleocytosis).
- All patients received dexamethasone treatment, survived, and were referred for further neurological follow-up.
Impact:
- This study underscores the importance of considering neurocysticercosis in the differential diagnosis of acute meningitis.
- Effective management with dexamethasone can lead to favorable outcomes.
- Highlights the role of specific diagnostic tools in identifying this parasitic CNS infection.
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