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Less platelet damage in the curved vane centrifugal pump: a comparative study with the roller pump in open heart
T Nishinaka1, H Nishida, M Endo
1Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.
Insights
The Lifestream Centrifugal Pump (LCP) demonstrated reduced blood trauma during cardiopulmonary bypass (CPB) compared to roller pumps. This novel pump shows promise for open-heart surgery by minimizing damage to blood components.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Hematology
Background:
- Cardiopulmonary bypass (CPB) is essential for open-heart surgery but can cause blood trauma.
- Centrifugal pumps are increasingly used in CPB, with ongoing research into their impact on blood components.
- The Lifestream Centrifugal Pump (LCP) is a novel curved-vane centrifugal pump designed to potentially minimize blood trauma.
Purpose of the Study:
- To evaluate the clinical performance of the Lifestream Centrifugal Pump (LCP) during cardiopulmonary bypass (CPB).
- To compare the LCP's effect on blood trauma markers with a conventional roller pump (RP).
- To assess hemodynamic performance and blood component integrity during CPB using the LCP.
Main Methods:
- Prospective study involving 10 patients undergoing elective coronary artery bypass grafting with LCP during CPB.
- Blood samples were collected to measure serum hemoglobin, platelet counts, and beta-thromboglobulin (beta-TG) levels.
- Results were compared to a control group of 10 patients who underwent CPB using a roller pump (RP).
Main Results:
- No significant difference in CPB duration between LCP and RP groups.
- Significantly lower serum beta-TG levels were observed in the LCP group compared to the RP group at multiple time points (p < 0.05).
- No significant differences in hemolysis or platelet depletion were found between the two pump types.
Conclusions:
- The Lifestream Centrifugal Pump (LCP) exhibits excellent hemodynamic performance.
- The LCP demonstrates reduced blood trauma, indicated by lower beta-TG levels, during clinical application in open-heart surgery.
- The LCP represents a promising alternative to roller pumps for minimizing blood damage in CPB procedures.
Abstract:
The centrifugal pump with the curved vane (Lifestream Centrifugal Pump [LCP]) was applied to cardiopulmonary bypass (CPB) in 10 patients who underwent elective coronary artery bypass grafting. Serum hemoglobin levels, platelet counts, and serum beta-thromboglogulin (beta-TG) levels were measured during CPB. The results were compared with those for a comparative roller pump (RP) group (n = 10). There was no difference in CPB time between LCP (112 +/- 22 min) and RP (121 +/- 22 min) groups. Serum beta-TG levels (ng/ml) were lower in the LCP group than in the RP group (34 +/- 9 vs. 101 +/- 80, 5 min; 81 +/- 33 vs. 236 +/- 112, 30 min; 120 +/- 53 vs. 314 +/- 100, 60 min after initiation of CPB; p < 0.05). There were no significant differences in hemolysis and platelet depletion. The LCP showed excellent hemodynamic performance with less blood trauma in clinical application to open heart surgery.