[Development of the cellular immunity reaction to tuberculin in mice of different genotypes]

Mice of the CBA, C57BL lines and the F1 (CBA X C57BL) hybrids were immunized intraperitoneally with tuberculin in complete Freund's adjuvant; production of the factor inhibiting the macrophage migration (MIF) by lymphocytes of different localization was studied. The lymphocytes are included into the MIF production in a definite order: first the cells of the peritoneal exudate, then-the cells of lymphatic nodes and last-the spleen cells. The C57BL mice demonstrated the maximal and earlier MIF production by the lymphocytes of the peritoneal exudate. Increasing spontaneous microphage migration, more expressed in the CBA mice, was noted after the immunization.