Peritoneal filtration fraction (PFF)

The aim of these studies was an evaluation of peritoneal filtration fraction (PFF) in uremic patients dialyzed using 1.5% glucose peritoneal dialysis solution: 1. with pH 6.22 +/- 0.01, without any drugs; 2. adjusted to pH 7.25 +/- 0.02 with 1 M NaOH, without any drugs; 3. as 1. but with the addition of sodium nitroprusside (5 mg/L); 4. as 1. but with the addition of chlorpromazine (2.5 mg/L); 5. as 1. but with the addition of isoprenaline HCL (0.5 mg/L). Investigations with every kind of solution (1.-5.) were carried out in 10 patients. PFF (%) was calculated as [formula: see text] where nUFR (mL/min) = net ultrafiltration rate; Hct (L/L) = hematocrit; EPBF (mL/min) = effective peritoneal capillary blood flow estimated as diffusive mass transfer coefficient of carbon dioxide gas. It was shown that alkalinization of dialysis solution, sodium nitroprusside, or chlorpromazine do not influence PFF, whereas isoprenaline HCL (0.5 mg/L) increases PFF when added to the dialysis solution of pH = 6.22.