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[Virus inactivated plasma]

M Köhler1, J U Wieding

  • 1Abteilung Transfusionsmedizin, Klinik der Universität Göttingen.

Infusionstherapie Und Transfusionsmedizin
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Two virus-inactivated plasma products, methylene blue (MB) and solvent detergent (SD) plasma, are available. While SD plasma shows comparable efficacy to fresh frozen plasma, MB plasma

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Area of Science:

  • Blood product safety and efficacy
  • Viral inactivation technologies
  • Plasma derivative analysis

Background:

  • Germany offers two primary virus-inactivated plasma preparations: Methylene Blue (MB) and Solvent Detergent (SD) plasma.
  • Both methods aim to mitigate viral transmission risks in transfusion medicine.

Purpose of the Study:

  • To compare the characteristics and clinical implications of MB and SD plasma.
  • To evaluate the efficacy and safety profiles of these two plasma products.

Main Methods:

  • MB plasma undergoes photoxidation with methylene blue and visible light.
  • SD plasma is treated with Triton X-100 and tri-n-butyl phosphate after pooling donations.
  • Analysis of viral reduction, protein alterations (fibrinogen, protein S, alpha-2-antiplasmin), and clinical efficacy.

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Main Results:

  • MB plasma photoxidation inactivates HIV by over 5 log10 but alters fibrinogen, with unclear clinical significance.
  • SD plasma treatment reduces HIV and hepatitis viruses by 5–6 log10 and decreases protein S and alpha-2-antiplasmin by approximately 40%.
  • Clinical studies indicate SD plasma's efficacy is comparable to untreated fresh frozen plasma.

Conclusions:

  • SD plasma demonstrates established efficacy and safety, comparable to fresh frozen plasma.
  • Further clinical studies are needed to ascertain the clinical significance of fibrinogen alterations in MB plasma.
  • Both MB and SD plasma represent advancements in ensuring safer blood transfusions.