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[Ankylosing gout. Apropos of 2 cases]
B Cortet1, B Duquesnoy, I Amoura
1Service de Rhumatologie, Centre A. Verhaeghe, CHRU de Lille.
Revue Du Rhumatisme (Ed. Francaise : 1993)
|January 1, 1994
Summary
Ankylosis, or joint fusion, is a rare complication of gouty arthritis. This study presents two new cases, highlighting the condition
Area of Science:
- Rheumatology
- Orthopedics
- Gout Research
Background:
- Ankylosis of joints due to gouty arthritis is exceptionally rare, with only ten previous cases reported.
- Typically, affected individuals have chronic, tophaceous gout that has been inadequately managed.
- This condition involves the fusion of joints, leading to significant loss of mobility.
Observation:
- Two new cases of gouty arthritis-induced ankylosis are presented.
- One patient lacked a documented history of acute gout, emphasizing atypical presentations.
- Affected joints included ankles, proximal interphalangeal joints of the hands, and wrists, with radiographic evidence of tarsal, tibiotarsal, and carpal ankylosis.
Findings:
- Pathological examination reveals a pannus rich in urate crystals within the affected joints.
- While antihyperuricemic agents can reduce urate deposition, they do not reverse established ankylosis.
- The precise pathophysiology linking gouty arthritis to joint fusion remains poorly understood.
Implications:
- These findings underscore the importance of recognizing ankylosis as a potential, albeit rare, complication of gout.
- Further research is needed to elucidate the mechanisms driving ankylosis in gouty arthritis.
- Current treatments targeting hyperuricemia do not resolve existing joint fusion, necessitating exploration of novel therapeutic strategies.