[Evaluation of the state of systemic and local cellular immunity using loading tests]

Area of Science:

• Immunology
• Pediatric Gastroenterology

Background:

• Cellular immunity plays a crucial role in gastrointestinal health.
• Understanding immune responses in children with chronic digestive conditions is vital for effective treatment.

Purpose of the Study:

• To investigate local and systemic cellular immunity parameters in children with chronic gastritis, duodenitis, celiac disease, secondary malabsorption, and phosphate diabetes.
• To classify T lymphocyte responses and develop interpretative coefficients for blood and gastrointestinal mucosa immunocompetent cells.

Main Methods:

• Studied 165 children with various gastrointestinal disorders.
• Utilized the spontaneous E-RFC method with in vitro loading tests.
• Applied thymalin, theophylline, and cold incubation for analysis.

Main Results:

• Identified three distinct types of T lymphocyte responses: hypoergic, resistant, and hyperergic.
• Developed coefficients to aid in interpreting immunocompetent cell responses in blood and gastrointestinal mucosa.
• Provided insights into cellular immunity variations in pediatric gastrointestinal diseases.

Conclusions:

• The classification of T lymphocyte responses offers a framework for understanding immune status in children with these conditions.
• The developed coefficients can assist clinicians in interpreting cellular immunity data.
• Further research can build upon these findings to improve diagnostic and therapeutic strategies for pediatric gastrointestinal disorders.