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Gastrointestinal cancer

R M Thomas1, L H Sobin

  • 1Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

Cancer
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Digestive tract cancer incidence and prognosis vary significantly by location and histology. Analyzing by histologic type is crucial for accurate assessment of these cancers.

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Cancer incidence and prognosis differ across digestive tract sites.
  • Histologic tumor types within these sites also exhibit varied incidence and survival rates.

Purpose of the Study:

  • To analyze the frequency, incidence, staging, and survival of various histologic types of digestive tract cancers.
  • To identify differences in cancer patterns based on race, sex, and time trends.

Main Methods:

  • Utilized Surveillance, Epidemiology, and End Results (SEER) data from 1973 to 1987.
  • Studied 194,452 cases of cancers of the esophagus, stomach, and intestines, examining various histologic types.

Main Results:

  • Increased incidence of adenocarcinomas in the esophagus, gastric cardia, small intestine, and colon; stable rates for rectal adenocarcinoma and esophageal squamous cell carcinoma; decreased gastric adenocarcinoma rates.

Related Experiment Videos

  • Racial disparities observed: Blacks had higher rates for gastric adenocarcinoma, esophageal squamous cell carcinoma, carcinoids, and gastric sarcomas. Whites had higher rates for esophageal and gastric cardia adenocarcinomas.
  • Mucinous colorectal carcinomas appear biologically distinct. Males generally had poorer survival than females. Appendiceal mucinous adenocarcinomas with metastases showed a 50% 5-year survival.

    • Conclusions:

    • Digestive tract cancer research necessitates detailed analysis by specific histologic type for accurate evaluation.
    • Understanding these variations is key for targeted prevention and treatment strategies.