[Analysis of neuropeptide release by brain microdialysis]

The application of the microdialysis technique for the analysis of neuropeptide release was described. The recoveries of neuropeptides are affected by the nature of the dialysis membrane, the sort of perfusion method, the internal diameter and length of the outlet tube, and the flow rate of the perfusate. The studies on the mechanism of neuropeptide release using brain microdialysis were summarized. Brain microdialysis technique allows the direct and dynamic analysis of neuropeptide release and provides a useful tool for studying the mechanism of the central regulation of the release of neuropeptides.