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The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761
L Marcocci1, J J Maguire, M T Droy-Lefaix
1Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Biochemical and Biophysical Research Communications
|June 15, 1994
Abstract:
Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.