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Pro-thrombotic states and their diagnosis
1Cattedra di Angiologia, Policlinico S. Orsola-Malpighi, Bologna.
Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|January 1, 1994
Summary
Pro-thrombotic states encompass thrombophilias with specific causes and conditions predisposing to thrombosis (CPT) with multiple mechanisms. Hypercoagulability is a transient laboratory finding, distinct from clinical states.
Area of Science:
- Hematology
- Clinical Pathology
- Epidemiology
Background:
- Pro-thrombotic states are defined by their association with a high frequency of thrombosis.
- These states are categorized based on pathogenetic, clinical, or epidemiological relationships.
Purpose of the Study:
- To clarify the definitions and distinctions between various pro-thrombotic conditions.
- To differentiate between thrombophilia, conditions predisposing to thrombosis (CPT), and hypercoagulability states.
Main Methods:
- Review and synthesis of existing literature on thrombosis and coagulation disorders.
- Analysis of pathogenetic mechanisms, clinical presentations, and epidemiological data.
- Identification of specific laboratory markers for hypercoagulability.
Main Results:
- Thrombophilic states have specific causes (e.g., inherited deficiencies, antiphospholipid antibodies).
- Conditions predisposing to thrombosis (CPT) involve multiple, less specific mechanisms (e.g., malignancy, diabetes).
- Hypercoagulability is a laboratory state of "activation of blood coagulation" with transient markers, distinct from clinical conditions.
Conclusions:
- Clear differentiation between thrombophilia, CPT, and hypercoagulability is crucial for accurate diagnosis and management.
- Hemostatic risk factors for atherothrombosis represent epidemiological associations, not necessarily hypercoagulability.