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Updated: Jul 29, 2026
Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
[Results of radionuclide ventriculography and correlation with echocardiography and angiography]
J Brousil1, O Bĕlohlávek, V Foltýnová
1Ustavy biofyziky a nukleární medicíny a II. interní klinika l. lékarské fakulty Univerzity Karlovy v Praze, Ceská republika.
Insights
This study compared methods for measuring heart function in coronary artery disease patients. Radionuclide ventriculography (RNVG) methods showed good correlation with radiological angiography (RTG) for most measurements, except for systolic volume (SV).
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Accurate measurement of left ventricular volumes and ejection fraction is crucial for managing coronary artery disease (CAD).
- Various imaging modalities, including radiological angiography (RTG), echocardiography (USG), and radionuclide ventriculography (RNVG), are used for these assessments.
- Understanding the comparative accuracy and variability of these methods is essential for clinical decision-making.
Purpose of the Study:
- To compare the correlation of left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), systolic volume (SV), and ejection fraction (EF) measurements.
- To evaluate different calculation methods within radionuclide ventriculography (RNVG) against radiological angiography (RTG) and echocardiography (USG).
- To assess the interpersonal variability of RNVG evaluations.
Main Methods:
- Retrospective analysis of 24 patients with coronary artery disease.
- Comparison of measurements obtained via RTG, USG, and RNVG.
- RNVG volume calculations included geometrical (GEO), scintigraphic image depth (VZ1), and body size-adjusted depth (VZ2) methods.
- Interpersonal variability of RNVG was assessed simultaneously.
Main Results:
- RNVG methods GEO and VZ2 demonstrated the best correlation with RTG for EDV (r=0.83, r=0.82) and ESV (r=0.91).
- Echocardiography (USG) showed the best correlation for EF, with GEO and VZ2 also showing good correlation (r=0.85).
- Systolic volume (SV) measurements exhibited very low correlation (r=0.39-0.50) across methods, rendering them practically useless.
- Overestimation of low values and underestimation of high values were observed.
- Interpersonal variability in RNVG evaluations was minimal.
Conclusions:
- RNVG methods, particularly GEO and VZ2, offer reliable correlations with RTG for EDV and ESV measurements in CAD patients.
- USG provides the best correlation for EF, while RNVG methods also show good agreement.
- SV measurements are unreliable across the studied modalities, limiting their clinical utility.
Abstract:
In a group of 24 patients with coronary artery diseases, correlations of left ventricle end-diastolic volume (EDV), end-systolic volume (ESV), systolic volume (SV), and ejection fraction (EF) measurement results were assessed. Compared results were obtained with radiological angiography (RTG), echocardiography (USG), and radionuclide ventriculography (RNVG). In RNVG, the left ventricle volume was calculated using a geometrical method (GEO), a sample method with measurement of left ventricle position depth from a scintigraphic image (VZ1), and a sample method with assessment of left ventricle position depth from body height and body weight (VZ2). Interpersonal variability of RNVG evaluation was assessed simultaneously. Compared with RTG, the best correlation of EDV measurement was attained with GEO (r = 0.83) and VZ2 (r = 0.82). These methods correlate best also in ESV measurement (r = 0.91). The best correlation of EF values was obtained with USG, while r = 0.85 when using GEO and VZ2. A very low correlation was found in SV (r values from 0.39 to 0.50). The studied methods usually overestimate low values and underestimate higher values. To the EF value of 50 per cent corresponds in USG the value 48 per cent, in GEO and VZ2 the value 42 per cent. The values of EDV, ESV, and SV obtained with USG and RNVG correlate well with RTG, while the values of SV are, due to a low correlation, practically useless. Interpersonal variability of RNVG methods evaluation is minimal. (Tab. 6, Ref. 30.)
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