Related Experiment Videos
Ovarian involvement by serous surface papillary carcinoma
T J Mulhollan1, E G Silva, C Tornos
1Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston.
Summary
Serous surface papillary carcinoma (SSPC) shows similar short-term survival to serous carcinoma of the ovary (SCO). However, SSPC demonstrates significantly better long-term survival rates at 48 months compared to SCO.
Area of Science:
- Gynecologic Oncology
- Pathology
- Clinical Cancer Research
Background:
- Serous surface papillary carcinoma (SSPC) is a peritoneal tumor with potential for ovarian involvement.
- SSPC is considered more aggressive than conventional serous carcinoma of the ovary (SCO).
Purpose of the Study:
- To compare the clinical outcomes and survival rates of SSPC and SCO.
- To evaluate the prognostic significance of tumor size in SSPC.
Main Methods:
- Retrospective analysis of 87 high-grade, stage III serous ovarian carcinomas with residual disease and ≥4-year follow-up.
- Comparison of 33 SSPC cases (tumors <10 mm) with 54 SCO cases (tumors >5.0 cm).
- Subdivision of SSPC into smaller (<5 mm) and larger (5.1-10 mm) groups, with subsequent recombination due to lack of statistical significance.
Main Results:
- No statistically significant difference in 24-month survival (39% vs. 32%) or median survival (17 vs. 18 months) between SSPC and SCO.
- A statistically significant difference in 48-month survival rates, with SSPC at 28% and SCO at 9% (p=0.027).
- Subdivision of SSPC by tumor size (
Conclusions:
- SSPC and SCO exhibit similar short-term survival.
- SSPC demonstrates a significantly improved long-term survival rate at 48 months compared to SCO.
- Tumor size within the defined range does not appear to be a significant prognostic factor for SSPC.