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[Study on cutaneous physio-immuno-pathological status in tinea versicolor]
1Department of Dermatology, Min-Shen Municipal Hospital, Kaohsiung City, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi = the Kaohsiung Journal of Medical Sciences
|April 1, 1994
Summary
Tinea versicolor lesions show reduced skin hydration and oil, with higher pH. This fungal infection may trigger a mild immune response in the skin's outer layer.
Area of Science:
- Dermatology
- Mycology
- Immunology
Background:
- Tinea versicolor is a common superficial fungal infection.
- The pathogenesis involves the yeast Malassezia.
- Understanding skin changes in tinea versicolor is crucial for treatment.
Purpose of the Study:
- To investigate the dermato-physiological, immunological, and pathological characteristics of tinea versicolor lesions.
- To compare these characteristics with normal skin.
Main Methods:
- Dermato-physiological measurements (sebum, hydration, pH) were performed on 20 tinea versicolor lesions and 20 controls.
- Immunohistochemical staining for IL-1 alpha was conducted.
- Stratum corneum cell layers, involucrin, and filaggrin were assessed.
Main Results:
- Lesions exhibited decreased sebum secretion and water content.
- Increased skin surface pH was observed in lesional sites.
- Weak positive staining for IL-1 alpha was noted in lesions, suggesting a localized immune response.
Conclusions:
- Altered skin physiology (reduced hydration, increased pH) may promote Malassezia growth.
- The observed IL-1 alpha suggests a mild inflammatory reaction in the stratum corneum.
- Profuse sweating might contribute to the destruction of the skin's acid mantle, facilitating infection.