[Collagen disease and vasculitis with manic and depressive symptoms]

Collagen diseases and vasculitis diseases are known to have severe disorders in many organs. Manic and depressive symptoms are also found in these diseases as one of central nervous system disorders. They are frequently observed in systemic lupus erythematosus, primary Sjögren's syndrome and rheumatoid arthritis. It is very difficult to diagnose and treat the manic-depressive states because there are many origins that cause the psychological disorder; immunological disorders (anti-cardiolipin antibodies, anti ribosomal protein P etc.), cerebral vasculitis, thrombosis, infections, endocrinological disorders, steroid induced psychosis and so on. There are few pathogenic studies to explain the manic-depressive symptom in these diseases.