Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study

M Goldenfeld1, T Krupin, J M Ruderman

  • 1Department of Ophthalmology, Northwestern University, Chicago, Illinois.

Ophthalmology
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal nerve fiber layer loss in pigment dispersion syndrome.

European journal of ophthalmology·2017
Same author

Baseline mean deviation and rates of visual field change in treated glaucoma patients.

Eye (London, England)·2011
Same author

Comparisons of anterior segment biometry between Chinese and Caucasians using anterior segment optical coherence tomography.

The British journal of ophthalmology·2010
Same author

Effects of topical k-strophanthin on aqueous humor and corneal dynamics.

Journal of glaucoma·2009
Same author

A comparison between microperimetry and standard achromatic perimetry of the central visual field in eyes with glaucomatous paracentral visual-field defects.

The British journal of ophthalmology·2009
Same author

Posterior chamber volume does not change significantly during dilation.

The British journal of ophthalmology·2009
Same journal

Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy.

Ophthalmology·2026
Same journal

Access to Intravitreal Anti-VEGF Drugs in Persons with Medicare Advantage Compared with Medicare Fee-For-Service.

Ophthalmology·2026
Same journal

Cataract Surgery and the Risk of Conversion from Dry to Neovascular Age-related Macular Degeneration in the IRIS© Registry.

Ophthalmology·2026
Same journal

Glaucoma in UK Biobank: A Comparison of Diagnostic- Versus Treatment-based Definitions.

Ophthalmology·2026
Same journal

Association between GLP-1 receptor agonist use and NAION with optic disc drusen.

Ophthalmology·2026
Same journal

The Effects of a Digital Mindfulness Intervention on Mental Health and Vision-Related Quality of Life in Non-infectious Uveitis.

Ophthalmology·2026
See all related articles

Postoperative 5-fluorouracil (5-FU) injections improved outcomes for initial trabeculectomy in open-angle glaucoma patients. This treatment lowered intraocular pressure and reduced medication needs, enhancing surgical success.

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Pharmacology

Background:

  • Filtration surgery is a common treatment for glaucoma.
  • Adjunctive therapies are often needed to improve surgical success rates.
  • 5-fluorouracil (5-FU) has shown promise in enhancing filtration surgery outcomes.

Purpose of the Study:

  • To evaluate the safety and efficacy of subconjunctival 5-fluorouracil (5-FU) injections in patients undergoing initial trabeculectomy for open-angle glaucoma.
  • To determine if 5-FU can improve intraocular pressure control and reduce medication requirements post-surgery.

Main Methods:

  • A prospective study involving patients with phakic, uncontrolled, open-angle glaucoma undergoing initial trabeculectomy.
  • Patients were randomized into two groups: a 5-FU group receiving five postoperative injections and a control group receiving no injections.

Related Experiment Videos

  • Follow-up was conducted for at least 1 year, monitoring intraocular pressure (IOP), medication use, and surgical success endpoints.

    • Main Results:

    • The 5-FU group (n=32) showed significantly lower mean IOP (12.0 mmHg) and fewer medications (0.2) at follow-up compared to the control group (n=30) (IOP 16.8 mmHg, medications 0.8).
    • A higher percentage of 5-FU eyes achieved target IOPs (≤20 mmHg: 94% vs 73%; ≤16 mmHg: 84% vs 57%).
    • Transient superficial punctate keratopathy was the only complication more frequent in the 5-FU group, but it was mild and temporary.

    Conclusions:

    • Adjunctive subconjunctival 5-fluorouracil (5-FU) significantly increases the success rate of initial trabeculectomy in open-angle glaucoma.
    • 5-FU treatment leads to a notable decrease in postoperative intraocular pressure and reduces the need for antiglaucoma medications.
    • The use of 5-FU is a safe and effective adjunct to trabeculectomy, improving long-term IOP control.