[Level of endothelin-1 and 2 in plasma of patients with chronic renal failure]

The aim of the study was to answer 3 questions: 1. does plasma endothelin level differ in patients with chronic renal failure from that of healthy subjects. 2. does plasma endothelin level differ in patients with chronic renal failure treated with haemodialysis from those treated without dialysis. 3. does plasma endothelin level change during haemodialysis. 63 patients with chronic renal failure (pnn, 23 treated without dialyses and 40 with dialyses) as well as 20 healthy subjects were studied. Plasma endothelin and creatinine were estimated under basal conditions and in the dialysed patients--immediately after dialysis. Plasma endothelin level was higher in patients with pnn than in normals, regardless to dialysotherapy. It rose after dialysis. Plasma creatinine fell after dialysis. Positive significant correlation was found between the levels of creatinine and endothelin in the whole group studied.