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[Effects of processing on special toxicity and pharmacodynamics in semen Armeniacae amarum]
1Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Abstract:
The ethereal extract and decoction from raw Semen Armeniacae Amarum were found to induce EBV-EA activation in Raji cells cultured in vitro. Experiments show that both the extract and decoction have tumor-promoting activities, but the EBV-EA activation can be decreased by three kinds of processing-parching, scalding or parching after scalding, of which parching and parching after scalding are better. Moreover, parching after scalding is the best to enhance the relaxing of bowels, inactivate the amygdalase and increase the decoction rate of amygdalin.
Insights
Raw apricot seed extracts can activate Epstein-Barr virus-early antigen (EBV-EA) and promote tumors. Processing methods like parching or scalding reduce this activation, with parching after scalding being most effective.
Area of Science:
- Pharmacology
- Traditional Chinese Medicine
- Oncology
Context:
- Semen Armeniacae Amarum (bitter apricot seed) is used in traditional medicine.
- Its raw extract and decoction activate Epstein-Barr virus-early antigen (EBV-EA) in vitro.
- This activation is linked to potential tumor-promoting activities.
Purpose:
- To investigate the effect of processing methods on Semen Armeniacae Amarum's EBV-EA activating properties.
- To evaluate the impact of processing on tumor-promoting activities.
- To identify optimal processing for inactivating amygdalase and enhancing amygdalin extraction.
Summary:
- Raw Semen Armeniacae Amarum extract and decoction induce EBV-EA activation in Raji cells.
- Processing methods (parching, scalding, parching after scalding) reduce EBV-EA activation.
- Parching after scalding is the most effective processing method, also improving laxative effects, amygdalase inactivation, and amygdalin extraction.
Impact:
- Processing Semen Armeniacae Amarum can mitigate its potential oncogenic risks.
- Optimized processing enhances therapeutic properties and safety.
- Findings inform the use of processed Semen Armeniacae Amarum in medicinal applications.