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Bone mineral content of women with uterine fibromyomas
1Obstetrics Department, Free Universities of Brussels (VUB-ULB) Hôpital Saint-Pierre, Brussels, Belgium.
Objective:
To determine if the bone mineral content (BMC) of women suffering from fibroids is different from that of the reference population.
Design:
Cross-sectional retrospective study.
Participants:
Fifty-nine women suffering from fibroids, compared to the reference population.
Outcome Measures:
BMC was measured at the vertebral L2-L4 site (BMC-1) and at the midradius site (BMC-r).
Results:
The patients with fibroids exhibited no significant difference in BMC-r).
Results:
The patients with fibroids exhibited no significant difference in BMC-r, but had a significantly higher (P < or = .001) BMC-1 than the reference population.
Conclusion:
Since BMC-1 is mainly constituted by trabecular bone and BMC-r by cortical bone, and since trabecular bone is more sensitive to estrogens than cortical bone, it is suggested that a hyper-estrogenic state co-existing with fibroids may induce a slight protective factor against osteoporosis of the vertebral skeleton.