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Study of autogenous transposed ossicles, bone and cartilage in man
Clinical Otolaryngology and Allied Sciences
|January 1, 1976
Summary
Autogenous ossicular and bone transplants in chronic otitis surgery appear inert and are not rejected. However, transplanted cartilage remains viable, offering a potential alternative for reconstructive purposes.
Area of Science:
- Otolaryngology
- Surgical Pathology
- Tissue Transplantation
Background:
- Chronic otitis media often necessitates ossicular reconstruction.
- Autogenous tissues are frequently used for transplantation in otologic surgery.
- Understanding the viability and host response to these grafts is crucial.
Purpose of the Study:
- To evaluate the viability and host response of autogenous transposed ossicles, bone, and cartilage grafts.
- To compare the pathological findings in transplanted tissues with native ossicles.
Main Methods:
- Histopathological examination of 28 ossicles from chronic otitis, 12 autogenous transposed ossicles, 4 bone transplants, and 2 cartilage transplants.
- Assessment of tissue viability, inflammation, and signs of rejection.
Main Results:
- Transposed ossicles and bone transplants were largely found to be dead, exhibiting pathology similar to non-transposed ossicles.
- Transplanted cartilage demonstrated viability.
- Autogenous grafts showed no evidence of rejection and reduced chronic inflammation.
Conclusions:
- Autogenous ossicular and bone grafts in humans function as inert implants without rejection.
- Autogenous cartilage transplants have the potential to remain viable after transplantation in otologic surgery.