Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states
Related Experiment Video
Updated: Nov 11, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
J M Ricort1, J F Tanti, M Cormont
1Institut National de la Santé et de la Recherche Médicale, INSERM U 145, Faculté de Médecine, Nice, France.
Abstract:
Insulin-induced Glut 4 and Rab4 movements were studied in two insulin-resistant states. In adipocytes from streptozotocin diabetic rats, the amount of Glut 4 was decreased by 60%. The remaining Glut 4 molecules were translocated in response to insulin, and in parallel, Rab4 left the intracellular compartment. In contrast, in 3T3-L1 adipocytes rendered insulin-resistant by a prolonged insulin treatment, both Rab4 and Glut 4 remained in the intracellular compartment following an acute insulin stimulation. Those results illustrate a similar behavior of Glut 4 and Rab4 in two situations where insulin resistance results from different mechanisms, and add further support for a role of Rab4 in Glut 4 translocation.
Related Concept Videos
Insulin: The Receptor and Signaling Pathways
Insulin Secretory Vesicles
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
PI3K/mTOR/AKT Signaling Pathway
Dipeptidyl Peptidase 4 Inhibitors

