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Correlation between peripheral vascular resistance and time to peak flow during reactive hyperaemia
E Wahlberg1, P D Line, P Olofsson
1Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
European Journal of Vascular Surgery
|May 1, 1994
Summary
The time to reach peak hyperaemic flux (tp) accurately reflects limb vascular resistance. This laser Doppler method may serve as a quantitative indicator for blood flow impairment in patients with atherosclerosis.
Area of Science:
- Biomedical Engineering
- Vascular Physiology
- Medical Diagnostics
Background:
- Laser Doppler (tp) has been proposed for evaluating ischemic limbs and peripheral vascular resistance (PR).
- The relationship between tp and limb vascular resistance due to arterial stenosis requires further investigation.
Purpose of the Study:
- To investigate the relationship between the time to reach peak hyperaemic flux (tp) and changes in limb vascular resistance caused by arterial stenosis.
Main Methods:
- Forty postocclusive hyperemia tests were conducted on four pigs with induced arterial stenoses.
- Laser Doppler fluxmetry recorded postocclusive hyperemia; limb vascular resistance was measured via blood infusion or calculated from flow and pressure gradients.
Main Results:
- The time to peak hyperaemic flux (tp) showed a close correlation with total limb vascular resistance.
- Correlation coefficients were r = 0.83 (p < 0.0003) with blood infusion method and r = 0.86 (p < 0.0001) with calculated resistance.
Conclusions:
- The time to peak hyperaemic flux (tp) accurately reflects limb vascular resistance in an experimental model.
- tp may serve as a quantitative indicator of overall blood flow impairment and warrants evaluation in patients with lower-limb atherosclerosis.