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[Secondary sclerosing cholangitis and chemo-embolization with lipiodol]
J P Richardet1, T Lons, M Sibony
1Service d'Hépato-Gastroentérologie, Hôpital Jean-Verdier, Bondy.
Gastroenterologie Clinique Et Biologique
|January 1, 1994
Summary
Sclerosing cholangitis can occur after oily arterial chemoembolization, presenting with varied symptoms like liver abscesses or cholestasis. Ischemia is the likely cause, suggesting this complication may be underdiagnosed.
Area of Science:
- Hepatology
- Interventional Radiology
- Gastroenterology
Background:
- Oily arterial chemoembolization is a treatment for certain cancers.
- Sclerosing cholangitis is a serious liver disease affecting bile ducts.
Observation:
- Two patients developed sclerosing cholangitis following oily arterial chemoembolization.
- Clinical presentations included angiocholitis with liver abscesses and gradual cholestasis.
Findings:
- Endoscopic retrograde cholangiogram revealed common hepatic bile duct strictures.
- Histology showed small bile duct involvement and arteriolar endarteritis obliterans.
- Ischemia is proposed as the primary mechanism.
Implications:
- The prevalence of this complication may be underestimated due to non-specific symptoms.
- Further studies are needed to accurately determine the incidence and clinical impact.
- Awareness among clinicians is crucial for timely diagnosis and management.