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Related Experiment Videos

Artifacts in ultrasonic contrast agent studies

F Forsberg1, J B Liu, P N Burns

  • 1Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|May 1, 1994
PubMed
Summary
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Ultrasonic contrast agents, like Albunex and Levovist, can cause artifacts in Doppler studies. While color blooming and bubble noise are identifiable, increased peak Doppler shifts hinder pre- and post-contrast comparisons.

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Diagnostic Sonography

Background:

  • Intravenously injected microbubble contrast agents show promise for Doppler ultrasonography.
  • Sonographic contrast agent measurements are susceptible to several artifacts.
  • Understanding these artifacts is crucial for accurate diagnostic interpretation.

Purpose of the Study:

  • To identify and characterize artifacts associated with microbubble ultrasonic contrast agents.
  • To investigate the underlying causes of these artifacts using specific contrast agents.
  • To assess the clinical impact of identified artifacts on diagnostic management.

Main Methods:

  • Experiments were conducted using Albunex and Levovist ultrasonic contrast agents.
  • Agents were injected intravenously into both rabbit and human subjects.

Related Experiment Videos

  • Artifacts were observed and analyzed in color and spectral Doppler displays.

    • Main Results:

    • Three primary artifacts were identified: color blooming, increased maximum Doppler shift, and spectral bubble noise.
    • Color blooming results from increased flow signal strength shortly after injection.
    • Increased maximum Doppler shift is attributed to the limited dynamic range of spectral displays, while bubble noise may stem from microbubble breakdown or large bubbles.

    Conclusions:

    • Color blooming and spectral bubble noise artifacts are generally identifiable and do not impede diagnostic decisions.
    • The artifact of increased peak Doppler shifts is clinically significant, preventing reliable comparison of spectral parameters before and after contrast agent administration.
    • Further research may be needed to mitigate the impact of Doppler shift artifacts for improved quantitative analysis.