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[Antipyretic effect of tiaprofenic acid in children. Comparative study with paracetamol]
J F Duhamel1, M Guillot, J Brouard
1Service de pédiatrie, CHU de Caen, France.
Insights
Tiaprofenic acid and acetaminophen show similar effectiveness in reducing fever in children with upper respiratory tract infections. Both medications were well-tolerated, suggesting tiaprofenic acid as a viable alternative for pediatric fever management.
Area of Science:
- Pediatrics
- Pharmacology
- Infectious Diseases
Background:
- Fever is a common symptom in children, often associated with upper respiratory tract infections.
- Acetaminophen is a widely used antipyretic medication for pediatric fever.
- Evaluating alternative antipyretic agents is crucial for effective fever management in children.
Purpose of the Study:
- To compare the antipyretic efficacy of tiaprofenic acid with acetaminophen in children.
- To assess the safety and tolerance of tiaprofenic acid compared to acetaminophen.
Main Methods:
- A randomized, multi-center study involving 79 children aged 8 months to 9 years with fever.
- Participants received a single dose of either tiaprofenic acid (50 mg) or acetaminophen (100 mg).
- Rectal temperature was monitored over a 6-hour period to assess antipyretic activity.
Main Results:
- Tiaprofenic acid demonstrated comparable antipyretic effectiveness to acetaminophen.
- Both temperature reduction gradients and differences between groups showed similar efficacy.
- Good tolerance was reported for both tiaprofenic acid and acetaminophen groups.
Conclusions:
- Tiaprofenic acid is as effective as acetaminophen in treating fever associated with upper respiratory tract infections in children.
- Tiaprofenic acid presents a valuable alternative for pediatric fever management.
- Further research may explore long-term efficacy and broader applications of tiaprofenic acid.
Abstract:
The authors report the results of a randomised, multi-centric study comparing the antipyretic activity of tiaprofenic acid to that of acetaminophen. Seventy nine children of both sexes, aged 8 months to 9 years, having an average temperature at inclusion of 38.5 degrees C (+/- 0.5 degree C), received as a single dose 50 mg of tiaprofenic acid (3.7 +/- 0.9 mg/kg) (40 children) or 100 mg of acetaminophen (7.7 +/- 1.7 mg/kg) (39 children) for upper respiratory tract infection. The rectal temperature was taken regularly over a 6-hour period. Whatever the criteria considered (gradient between the initial temperature and the lowest temperature observed, difference of temperature at the different time points between the two groups), tiaprofenic acid appeared as effective an antipyretic as acetaminophen. Tolerance was good in both groups. Tiaprofenic acid appears as an interesting alternative to acetaminophen in the treatment of fever in upper respiratory tract infections in children.