Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunosuppressive drugs and their effects

K R Superdock1, J H Helderman

  • 1Division of Nephrology, Vanderbilt University Medical Center, Nashville.

Seminars in Respiratory Infections
|September 1, 1993
PubMed
Summary

Improvements in immunosuppressive drugs have advanced organ transplantation success. Understanding immunosuppressant mechanisms and side effects is key to developing more specific agents or tolerance protocols for better long-term organ survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistent shortness of breath in a kidney transplant recipient.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Rapid murine mixed lymphocyte cultures assessed by emergence of T-cell insulin receptors.

Immunogenetics·2011
Same author

Calcineurin inhibitor avoidance versus steroid avoidance following kidney transplantation: Postoperative complications.

Transplantation proceedings·2006
Same author

Short-term results under three different immunosuppressive regimens at one center.

Transplantation proceedings·2006
Same author

Mortality after kidney transplantation: what lessons can we learn from regional and country variation?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
Same author

Kidney transplantation in a veterans administration medical center: 40 years' experience.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2005

Area of Science:

  • Immunology
  • Pharmacology
  • Transplantation Medicine

Background:

  • Organ transplantation success has increased due to improved immunosuppressive strategies.
  • These strategies are crucial for managing immune responses in patients with diabetes mellitus and end-stage organ diseases.

Purpose of the Study:

  • To review the immune response in organ transplantation.
  • To elucidate the mechanisms of action for various immunosuppressive agents.
  • To discuss the efficacy, side effects, and future directions in immunosuppression.

Main Methods:

  • Review of existing literature on immunosuppressive drugs and their mechanisms.
  • Analysis of the immune response in the context of organ transplantation.
  • Discussion of specific immunosuppressants including azathioprine, glucocorticoids, cyclosporine A/G, FK506, rapamycin, mycophenolic acid/mofetil, mizoribine, brequinar sodium, and deoxyspergualine.

Main Results:

  • Immunosuppressants reviewed exhibit varied mechanisms affecting the immune response.
  • The efficacy of these agents is often accompanied by significant, predictable side effects due to their nonspecificity.
  • Understanding these mechanisms aids in predicting and managing adverse events.

Conclusions:

  • Current immunosuppressants, while effective, cause significant side effects.
  • Development of more specific immunosuppressants is needed.
  • Inducing organ tolerance through novel protocols could lead to long-term graft survival without complications.

Related Experiment Videos