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Updated: Aug 12, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Recent advances in the development of anticancer drugs that act against signalling pathways

G Powis1

  • 1Arizona Cancer Center, University of Arizona Health Sciences Center, Tucson 85724.

Tumori
|April 30, 1994
PubMed

Insights

Targeting cancer

Area of Science:

  • Oncology and molecular biology

Background:

  • Cancer is characterized by disrupted intracellular signaling pathways.
  • Oncogenes drive cell growth and transformation through these pathways.

Purpose of the Study:

  • To explore the potential and challenges of developing anticancer drugs that target intracellular signaling pathways.
  • To review current and developing drugs that inhibit these pathways.

Main Methods:

  • Review of existing literature on signaling pathway inhibitors in cancer therapy.
  • Analysis of drugs currently in clinical trials and under development.

Main Results:

  • Intracellular signaling pathways are promising targets for novel anticancer drug development.
  • Several drugs disrupting these pathways are in clinical trials or development.

Conclusions:

  • Targeting intracellular signaling pathways represents a novel and promising approach to cancer treatment.
  • Further research and development are needed to overcome challenges and optimize these therapies.

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