[Carbohydrate metabolic disorder in women with a neuroendocrine syndrome]

A total of 129 women with the neuroendocrine syndrome were examined. A clinico-biochemical heterogeneity of the disease was revealed. One group included patients with the android type of fat deposition, manifest hyperandrogenism, polycystic ovaries, and carbohydrate metabolism disorders (hyperinsulinemia, impaired glucose tolerance, insulin resistance). Severity of carbohydrate metabolism disorders in these patients was unrelated to obesity degree. The other group included patients with the gynoid type of fat deposition, weakly manifest hyperandrogenism signs, and body mass-dependent shifts in carbohydrate metabolism. It is possible that carbohydrate metabolism shifts contribute to the pathogenesis of the clinical picture of the neuroendocrine syndrome.