Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnetization transfer in multiple sclerosis

R I Grossman1

  • 1Division of Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia 19104-4283.

Annals of Neurology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral infarction during hypertensive encephalopathy: Case report with pathologic and atypical radiographic findings.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Non-Gaussian diffusion MRI of gray matter is associated with cognitive impairment in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2014
Same author

Imaging the effects of oxygen saturation changes in voluntary apnea and hyperventilation on susceptibility-weighted imaging.

AJNR. American journal of neuroradiology·2013
Same author

Functional homotopic changes in multiple sclerosis with resting-state functional MR imaging.

AJNR. American journal of neuroradiology·2013
Same author

Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study.

AJNR. American journal of neuroradiology·2012
Same author

Two-year serial whole-brain N-acetyl-L-aspartate in patients with relapsing-remitting multiple sclerosis.

Neurology·2012
Same journal

Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

Annals of neurology·2026
Same journal

Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

Annals of neurology·2026
Same journal

Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

Annals of neurology·2026
Same journal

Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

Annals of neurology·2026
Same journal

Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease.

Annals of neurology·2026
Same journal

The Financial Value of an Academic Neurologist.

Annals of neurology·2026
See all related articles

Magnetization transfer (MT) imaging detects myelin changes by saturating macromolecular protons. This technique quantifies myelin integrity using the magnetization transfer ratio (MTR), aiding in multiple sclerosis (MS) lesion characterization.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Magnetization transfer (MT) imaging leverages the macromolecular structure of myelin for detecting changes.
  • Myelin's rigid structure facilitates proton exchange, which is the basis for MT signal generation.
  • The magnetization transfer ratio (MTR) quantifies these changes in signal intensity.

Purpose of the Study:

  • To explore the utility of MT imaging in detecting myelin alterations.
  • To investigate the application of MTR in characterizing white matter lesions in multiple sclerosis (MS).
  • To assess the potential of MT in identifying abnormalities in normal-appearing white matter and enhancing lesion detection.

Main Methods:

  • Utilizing off-resonance irradiation to saturate macromolecular protons.

Related Experiment Videos

  • Quantifying signal intensity changes using the magnetization transfer ratio (MTR = (Mo-Ms)/Mo).
  • Applying MT imaging in an experimental autoimmune encephalomyelitis (EAE) model and in patients with MS.

    • Main Results:

    • MT imaging demonstrated sensitivity to white matter lesions, including those in EAE models and MS patients with apparent myelin loss.
    • Abnormal MTRs were observed in normal-appearing white matter in MS patients, not detectable by standard MRI.
    • MTRs allowed for subcategorization of MS lesions into demyelinating (low MTR) and edematous (high MTR) types.
    • Combined use of MT and gadolinium enhanced the detection of MS lesions and blood-brain barrier abnormalities.

    Conclusions:

    • MT imaging is a valuable tool for detecting myelin changes and assessing white matter integrity.
    • MTR provides a quantitative measure for characterizing MS lesions and identifying subtle abnormalities.
    • MT imaging, particularly with contrast agents, improves the detection of pathological changes in MS.