Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structures of Solids

Structures of Solids

Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...

Integrins

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...

Overview of Cell-Cell Junctions

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another cell. These cell junctions are classified into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...

Structure of Cadherins

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...

Cell Diversity

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...

Three-Dimensional Microscopy in Microbiology

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ultra-Early Diffuse Lung Disease in an Infant with Pathogenic Variant in Telomerase Reverse Transcriptase (<i>TERT</i>) Gene.

Balkan journal of medical genetics : BJMG·2024

Same author

Using a generative adversarial network to generate synthetic MRI images for multi-class automatic segmentation of brain tumors.

Frontiers in radiology·2024

Same author

Influence of COVID-19 Pandemic on Colorectal Cancer Presentation, Management and Outcome during the COVID-19 Pandemic.

Journal of clinical medicine·2023

Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Same author

Ambiguous Genitalia and Lissencephaly in A 46,XY Neonate with a Novel Variant of Aristaless Gene.

Acta endocrinologica (Bucharest, Romania : 2005)·2022

Same author

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS<sup>®</sup>) Society Recommendations: 2018.

World journal of surgery·2018

Same journal

Endocrine cells distribution in human proximal small intestine: an immunohistochemical and morphometrical study.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

Same journal

Ocular anatomy in medieval arabic medicine. A review.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

Same journal

Direct origin of the right colic artery from the abdominal aorta.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

Same journal

Ectopic third molar tooth on the infratemporal surface of maxilla.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

Same journal

Persistent median artery of the forearm and palm: a cadaver study into its origin, course, fate and clinical significance.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

Same journal

Morphological study of the effects of aqueous leaf extract of Xylopia aethiopica on the pancreas in diabetic rats.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia·2017

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Published on: October 27, 2013

The three-dimensional structure of interdigitating cells

E Crivellato¹, G Baldini, M Basa

¹Dipartimento di Ricerche Mediche e Morfologiche, Università di Udine.

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia

|October 1, 1993

Summary

This summary is machine-generated.

Interdigitating cells (IDCs) in lymph nodes and spleens form complex 3D networks. These intricate structures facilitate crucial interactions with T-lymphocytes, supporting immune responses.

More Related Videos

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Published on: March 21, 2019

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Published on: October 29, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Published on: October 27, 2013

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Published on: March 21, 2019

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Published on: October 29, 2019

Area of Science:

Immunology
Cell Biology
Microanatomy

Background:

Interdigitating cells (IDCs) play a key role in immune responses within lymphoid organs.
Understanding the precise 3D structure of IDCs is essential for elucidating their function in T-cell activation.

Purpose of the Study:

To investigate the in vivo three-dimensional architecture of mouse lymph node and spleen IDCs.
To characterize the spatial relationship between IDCs and lymphocytes.

Main Methods:

Computer-assisted 3D reconstruction from serial Epon-embedded sections.
Specific osmium-zinc iodide impregnation for IDC visualization.
Polystyrene model assembly for morphological analysis.

Main Results:

IDCs are large cells with extensive, complex 3D networks of cytoplasmic processes.
Flattened, sheet-like processes from IDCs envelop numerous lymphocytes and lymphoblasts.
Surface invaginations form channel-like structures within the IDC cytoplasm.

Conclusions:

The complex 3D IDC network provides a unique microenvironment for T-cell activation and proliferation.
Morphological evidence supports a strict physical interaction between IDCs and T-lymphocytes.
IDC-T lymphocyte aggregates represent a specialized microanatomical and functional unit.