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Severe hypodiploidy with karyotype instability in a case of acute myeloid leukemia
D R Betts1, O H Baugh, B Gibbons
1ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, England.
Cancer Genetics and Cytogenetics
|June 1, 1994
Abstract:
We present a case of acute myeloid leukemia (AML) in an elderly male. A severe hypodiploid karyotype (chromosome range 29-39) was detected with a large amount of cell-to-cell variation, suggesting that the leukemic cells are primarily characterized by chromosomal loss due to karyotypic instability. Severe hypodiploidy is a rare finding in AML but previous similar cases indicate that it confers a very poor prognosis.