[Changes in plasma TxB2 and 6-keto-PGF1 alpha in patients with retinal vein occlusion]

Plasma TxB2 and 6-keto-PGF1 alpha were measured in 16 patients with central retinal vein occlusion (CRVO) and 18 patients with branch retinal vein occlusion (BRVO) as well as 21 normal controls by radioimmunoassay. The results showed that the ratio of TxB2/6-keto-PGF1 alpha (T/P) was higher in CRVO or BRVO than in control. The prime reason of high T/P value was the increase of plasma TxB2 in CRVO, while the prime reason was the decrease of plasma 6-keto-PGF1 alpha in BRVO. The results indicate that the pathogenesis of CRVO is related to the high platelet aggregation and the changes in blood rheology or hemodynamics, while the pathogenesis of BRVO mainly depends on the pathologic changes of endothelium in systemic and retinal blood vessels.