[The distribution of class-I HLA antigens in patients with multiple myeloma]

HLA antigens class 1 have been investigated in Russian patients with multiple myeloma. Compared to controls, myeloma patients demonstrated more frequent occurrence of antigens A11 and B7. Antigen A11 was more common for males and subjects with early response to treatment. Antigen B7 was more frequent in females with the slow response. These correlations are significant without correction on the number of the antigens studied. Association heterogeneity in males and females, in different therapy responders gives grounds for a differential approach to myeloma pathogenesis, choice of drugs, prognosis of survival.