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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Cervical necrotizing fasciitis
1University of Minnesota, Department of Otolaryngology-Head and Neck Surgery, Minneapolis 55415-1829.
The Laryngoscope
|July 1, 1994
Summary
Necrotizing fasciitis of the neck, a severe soft-tissue infection, requires prompt surgical exploration and broad-spectrum antibiotics. Early airway management and intensive support, including hyperbaric oxygen for severe cases, are crucial for successful patient outcomes.
Area of Science:
- Infectious Diseases
- Head and Neck Surgery
- Bacteriology
Background:
- Necrotizing fasciitis is a rapidly progressive bacterial infection affecting the deep fascia and subcutaneous tissues.
- Cervical necrotizing fasciitis presents a significant threat to airway patency and can lead to severe morbidity and mortality.
- Understanding the diverse origins and polymicrobial nature of this infection is critical for effective management.
Purpose of the Study:
- To present a series of cervical necrotizing fasciitis cases.
- To analyze the origins, bacteriology, and treatment outcomes.
- To recommend optimal management strategies for this life-threatening condition.
Main Methods:
- Retrospective review of nine cases of cervical necrotizing fasciitis.
- Analysis of patient demographics, infection sources (odontogenic, pharyngeal, spider bite), and causative microorganisms.
- Evaluation of treatment protocols including antibiotics, surgical intervention, and adjunctive therapies.
Main Results:
- The nine cases included five odontogenic, three pharyngeal, and one spider bite origin.
- Bacteriological analysis revealed a polymicrobial infection involving gram-positive, gram-negative, and anaerobic bacteria.
- Initial treatment with third-generation cephalosporins and metronidazole or clindamycin showed successful outcomes.
Conclusions:
- Early airway control and wide surgical exploration of neck fascial spaces are paramount.
- Frequent reexploration is necessary to monitor treatment efficacy and disease progression.
- Intensive medical support, including hyperbaric oxygen for deteriorating patients, is advised.
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